Remember, the only thing scarier than findings is no findings. Go break some eggs.
Your Weekly Briefing:
👀 Insights
The 5 Questions That Decide Adversity
Every tox finding gets the same interrogation: dose response, reversibility, histopath correlation, biological significance, consistency across sex and species. In 10 minutes, I walk through the flowchart sponsors, study directors, and pathologists actually use to call a finding adverse — and what each answer means for your NOAEL.
💭 Myths v. Realities
Myth: Adverse effects are show stoppers that need to be avoided at all costs.
Reality: Adverse effects actually anchor your NOAEL, give you a foundation for your human starting dose, and provide usable threshold for toxicity in relation to the clinic. They are as meaningful to your tox study as TK is.
🔧 Tools
A checklist to help determine if a finding is adverse or not, and what to do next
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